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Chemelli et al (1999) examined fos-reactivity in orexin neurons of mice provided modafinil just before sacrifice and located a substantially increased activation of orexin neurons with modafinil than with placebo.elvitegravir/cobicistat/emtricitabine/tenofovir DF raises levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism.Al